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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K12
All Species:
19.09
Human Site:
T545
Identified Species:
35
UniProt:
Q12852
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12852
NP_006292.2
859
93219
T545
G
R
S
R
R
G
K
T
R
H
R
K
A
S
A
Chimpanzee
Pan troglodytes
XP_509099
871
93967
G559
D
A
A
L
S
G
V
G
L
P
G
C
P
K
G
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
T578
G
R
S
R
R
G
K
T
R
H
R
K
A
S
A
Dog
Lupus familis
XP_857182
860
93116
T545
G
R
S
R
R
G
K
T
R
H
R
K
A
S
A
Cat
Felis silvestris
Mouse
Mus musculus
Q60700
888
96066
T578
G
R
S
R
R
G
K
T
R
H
R
K
A
S
A
Rat
Rattus norvegicus
Q63796
888
96289
T578
G
R
S
R
R
G
K
T
R
H
R
K
A
S
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422689
966
107967
P591
K
S
R
Y
R
S
K
P
R
H
R
R
G
N
S
Frog
Xenopus laevis
A7J1T0
961
107551
K591
G
K
G
R
Y
R
S
K
P
R
H
R
R
G
N
Zebra Danio
Brachydanio rerio
NP_996977
856
94429
P547
V
L
Q
V
T
V
P
P
C
S
N
R
G
S
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
S580
T
S
T
H
S
S
F
S
K
S
A
P
N
L
D
Honey Bee
Apis mellifera
XP_397605
895
101116
K564
N
N
S
F
K
Q
R
K
Y
R
H
R
R
V
G
Nematode Worm
Caenorhab. elegans
O01700
928
103465
L569
G
A
N
P
P
K
I
L
R
N
D
A
I
R
H
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
Q564
I
R
A
K
T
L
P
Q
R
K
S
R
H
R
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.7
95.2
97.4
N.A.
92.5
91.7
N.A.
N.A.
52.3
51.8
65.4
N.A.
24
38.4
29
38.6
Protein Similarity:
100
95.8
95.6
98.5
N.A.
93.8
93.1
N.A.
N.A.
62.5
63.1
74
N.A.
38.4
52.8
44.9
52.8
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
N.A.
33.3
13.3
6.6
N.A.
0
6.6
13.3
13.3
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
N.A.
53.3
26.6
13.3
N.A.
20
26.6
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
16
0
0
0
0
0
0
0
8
8
39
0
39
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
8
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
8
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% F
% Gly:
54
0
8
0
0
47
0
8
0
0
8
0
16
8
16
% G
% His:
0
0
0
8
0
0
0
0
0
47
16
0
8
0
8
% H
% Ile:
8
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% I
% Lys:
8
8
0
8
8
8
47
16
8
8
0
39
0
8
0
% K
% Leu:
0
8
0
8
0
8
0
8
8
0
0
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
8
8
0
0
0
0
0
0
8
8
0
8
8
8
% N
% Pro:
0
0
0
8
8
0
16
16
8
8
0
8
8
0
0
% P
% Gln:
0
0
8
0
0
8
0
8
0
0
0
0
0
0
0
% Q
% Arg:
0
47
8
47
47
8
8
0
62
16
47
39
16
16
8
% R
% Ser:
0
16
47
0
16
16
8
8
0
16
8
0
0
47
8
% S
% Thr:
8
0
8
0
16
0
0
39
0
0
0
0
0
0
8
% T
% Val:
8
0
0
8
0
8
8
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
8
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _